Atrasentan Hydrochloride
Atrasentan Hydrochloride is an investigational selective endothelin A receptor antagonist that has been studied primarily for the treatment of diabetic kidney disease and certain malignancies. It works by blocking the action of endothelin-1, a potent vasoconstrictor peptide involved in kidney damage and tumor growth. Clinical development has focused on its potential renoprotective effects and anti-tumor properties, though its regulatory status varies by indication and region.
Atrasentan Hydrochloride is an endothelin A receptor antagonist that has been investigated for kidney disease and cancer treatment.
Key facts at a glance
- RxNorm
- 2710448
- Generic
- Atrasentan Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Investigated for diabetic nephropathy and chronic kidney disease, as well as certain cancers including renal cell carcinoma and prostate cancer. Not currently approved by major regulatory agencies for any indication.
Selectively blocks endothelin A receptors, preventing endothelin-1 from binding and causing vasoconstriction, inflammation, and fibrosis. This may reduce kidney damage and potentially inhibit tumor angiogenesis.
As an investigational agent, it is not widely available commercially. Common concerns include fluid retention and hepatotoxicity. Patients should only use under clinical trial protocols or physician supervision with appropriate monitoring.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy