Atropine / Chlorpheniramine / Ephedrine
This combination medication is used to temporarily relieve symptoms of the common cold, allergies, and hay fever, including nasal congestion, runny nose, sneezing, and itchy eyes. It contains three active ingredients that work together: an antihistamine (chlorpheniramine) to reduce allergic symptoms, a decongestant (ephedrine) to shrink swollen nasal passages, and an anticholinergic agent (atropine) to help dry excess respiratory secretions.
A combination cold and allergy medication that relieves congestion, runny nose, and sneezing through antihistamine, decongestant, and anticholinergic effects.
Key facts at a glance
- RxNorm
- 689596
- Generic
- Atropine / Chlorpheniramine / Ephedrine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves nasal congestion, sinus congestion, runny nose, sneezing, itchy nose and throat, and itchy, watery eyes associated with the common cold, allergic rhinitis, or other upper respiratory allergies.
Chlorpheniramine blocks histamine receptors to reduce allergic symptoms. Ephedrine constricts blood vessels in the nasal passages to reduce swelling and congestion. Atropine helps dry excessive respiratory secretions.
May cause drowsiness; avoid operating machinery or driving until you know how it affects you. Use with caution if you have heart disease, high blood pressure, thyroid disorders, diabetes, or glaucoma. Not recommended for use in children without medical supervision. Consult a healthcare provider before use if you are pregnant, breastfeeding, or taking other medications.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy