Atropine / Difenoxin
Atropine/Difenoxin is a combination medication used to treat acute and chronic diarrhea. Difenoxin works by slowing intestinal motility through opioid receptors, while atropine (an anticholinergic) helps reduce intestinal spasms and discourages misuse. This combination is typically prescribed when other anti-diarrheal treatments are insufficient.
A combination anti-diarrheal medication that slows gut motility and reduces intestinal spasms.
Key facts at a glance
- RxNorm
- 214261
- Generic
- Atropine / Difenoxin
- Class
- multi-ingredient
- Brands
- Motofen
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute and chronic diarrhea, including traveler's diarrhea and functional gastrointestinal disorders characterized by excessive intestinal motility.
Difenoxin binds to opioid receptors in the gastrointestinal tract, reducing peristalsis and allowing more fluid absorption. Atropine complements this action by blocking acetylcholine receptors, decreasing intestinal spasms and secretions.
May cause drowsiness or dizziness; avoid operating machinery. Not recommended for patients with obstructive bowel disease, bacterial enterocolitis, or pseudomembranous colitis. Should not be used longer than 10 days continuously. Keep out of reach of children due to atropine content. Common side effects include dry mouth, blurred vision, and constipation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy