Atropine / Diphenoxylate
Atropine/diphenoxylate is a combination anti-diarrheal medication used to treat acute and chronic diarrhea. It works by slowing intestinal movement through a dual mechanism, reducing both motility and intestinal secretions. This medication is typically prescribed when other anti-diarrheal treatments have not been effective.
A combination medication that treats diarrhea by slowing intestinal movement and reducing fluid secretion in the intestines.
Key facts at a glance
- RxNorm
- 594040
- Generic
- Atropine / Diphenoxylate
- Class
- multi-ingredient
- Brands
- Lomotil
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat acute non-specific diarrhea and chronic diarrhea associated with inflammatory bowel disease. Also sometimes used to manage traveler's diarrhea when other treatments are inadequate.
Diphenoxylate is an opioid agonist that acts on intestinal smooth muscle to reduce peristalsis and prolong transit time. Atropine is an anticholinergic that decreases intestinal secretions and motility. Together, they provide dual-action relief from diarrhea symptoms.
May cause drowsiness or dizziness; avoid operating machinery. Can produce opioid-like effects in high doses. Should not be used in patients with bacterial enteritis or toxic megacolon. Not recommended for children under 6 years old. Use cautiously in patients with liver disease or those taking other CNS depressants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy