Atropine / Meperidine
Atropine/Meperidine is a combination medication pairing an opioid analgesic with an anticholinergic agent. Historically used as pre-anesthetic medication before surgical procedures to provide sedation, reduce anxiety, and minimize respiratory secretions.
A combination opioid-anticholinergic medication historically used for pre-operative sedation and to reduce surgical complications.
Key facts at a glance
- RxNorm
- 689609
- Generic
- Atropine / Meperidine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for pre-anesthetic medication and as an adjunct during surgical procedures. May be employed for sedation and reduction of respiratory secretions during certain medical procedures.
Meperidine binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Atropine acts as an anticholinergic by blocking muscarinic acetylcholine receptors, reducing bronchial secretions and preventing reflex bronchospasm.
This combination is considered an older medication approach and is less commonly used in modern practice. Meperidine carries risks including potential neurotoxicity from its metabolite normeperidine, particularly with prolonged use or renal impairment. Use requires careful monitoring for respiratory depression, sedation, and potential dependence. Should only be used under direct medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy