Atropine / Phenobarbital
Atropine/Phenobarbital is a combination medication that pairs an anticholinergic agent with a barbiturate. Atropine blocks muscarinic acetylcholine receptors, reducing secretions and protecting against bradycardia, while phenobarbital enhances GABA activity producing sedation and anticonvulsant effects. This combination is used primarily in veterinary medicine for procedures requiring both antisecretory effects and sedation or seizure control.
A veterinary combination medication providing antisecretory and sedative/anticonvulsant effects for pre-procedural preparation and certain neurological conditions.
Key facts at a glance
- RxNorm
- 214263
- Generic
- Atropine / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used in veterinary practice for pre-anesthetic medication, to reduce salivary and respiratory secretions during procedures, and for conditions requiring both sedation and antisecretory effects. May also be used as an anticonvulsant in certain cases.
Atropine blocks muscarinic acetylcholine receptors, reducing secretions and protecting against bradycardia. Phenobarbital enhances GABA activity in the brain, producing CNS depression, sedation, and anticonvulsant effects. Together they provide both antisecretory and central nervous system depressant actions.
Should only be used under veterinary supervision. Side effects may include dry mouth, drowsiness, and altered heart rate. Animals with certain conditions such as glaucoma, urinary obstruction, or tachycardia may require alternative treatments. Dosage and monitoring should be directed by a veterinarian.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy