Atropine / Pralidoxime
Atropine/Pralidoxime is an emergency antidote combination used to treat poisoning from organophosphate insecticides or nerve agents. Atropine reverses the life-threatening effects of excessive acetylcholine, while pralidoxime helps restore normal nerve function by reactivating acetylcholinesterase. This medication is typically administered in emergency settings such as hospitals or by first responders during mass casualty events.
Atropine/Pralidoxime is an emergency antidote for organophosphate or nerve agent poisoning, working to counteract dangerous overstimulation of nerve function.
Key facts at a glance
- RxNorm
- 465370
- Generic
- Atropine / Pralidoxime
- Class
- multi-ingredient
- Brands
- Duodote
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute organophosphate or carbamate insecticide poisoning, as well as nerve agent exposure (including sarin, soman, tabun, and VX). Used in both civilian emergency medicine and military settings.
Atropine is an anticholinergic agent that blocks muscarinic receptors, counteracting excessive acetylcholine buildup. Pralidoxime (2-PAM) is a cholinesterase reactivator that binds to organophosphate molecules and restores acetylcholinesterase function, allowing normal nerve signaling to resume.
This is an emergency medication administered in controlled medical settings. Atropine is typically given first, often by injection (IV, IM, or endotracheal). Pralidoxime is most effective when given early before "aging" of the enzyme-inhibitor complex occurs. Patients require close monitoring and may need repeated dosing. Treatment does not replace supportive care such as airway management and respiratory support.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy