Avacincaptad Pegol Sodium
Avacincaptad pegol is a complement C5 inhibitor used to treat geographic atrophy (GA) secondary to age-related macular degeneration (AMD). It is administered via intravitreal injection and works by preventing complement-mediated damage to retinal cells, potentially slowing vision loss in affected patients.
Avacincaptad pegol is an eye injection medication for geographic atrophy associated with age-related macular degeneration that works by inhibiting complement C5.
Key facts at a glance
- RxNorm
- 2645107
- Generic
- Avacincaptad Pegol Sodium
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
Inhibits complement component C5, preventing its cleavage and subsequent formation of the membrane attack complex (MAC), thereby reducing complement-mediated retinal cell damage and degeneration
Administered as intravitreal injections by a healthcare professional. May increase risk of eye infections including endophthalmitis. Requires regular monitoring during treatment. Safety in pregnancy and breastfeeding has not been established. Patients should report any signs of infection or inflammation promptly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy