Avalglucosidase Alfa-Ngpt
Avalglucosidase Alfa-Ngpt is an enzyme replacement therapy used to treat Pompe disease (glycogen storage disease type II), a rare genetic disorder caused by buildup of glycogen in cells due to deficiency of the acid alpha-glucosidase enzyme. It is specifically indicated for patients with late-onset Pompe disease (LOPD).
An enzyme replacement therapy for treating Pompe disease by supplying the deficient acid alpha-glucosidase enzyme.
Key facts at a glance
- RxNorm
- 2565813
- Generic
- Avalglucosidase Alfa-Ngpt
- Class
- pin-variant
- Brands
- Nexviazyme
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of late-onset Pompe disease (LOPD) in patients aged 1 year and older. It helps manage the symptoms and slows disease progression in this rare genetic disorder affecting muscle function.
Replaces the deficient acid alpha-glucosidase enzyme through intravenous infusion. The recombinant enzyme is taken up by cells and transported to lysosomes where it breaks down accumulated glycogen.
Administered via intravenous infusion every 2 weeks at recommended dose of 20 mg/kg. May cause infusion-associated reactions including hypersensitivity. Requires cardiac monitoring in some patients. Must be administered in appropriate clinical setting.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy