Avibactam / Aztreonam
Avibactam/aztreonam is a combination antibiotic used to treat serious gram-negative bacterial infections, particularly those caused by organisms resistant to standard antibiotics. This combination is especially valuable for infections involving bacteria that produce certain beta-lactamase enzymes, which would otherwise render many antibiotics ineffective. It is typically reserved for complex infections such as complicated intra-abdominal infections, urinary tract infections, and hospital-acquired pneumonia when resistant organisms are suspected or confirmed.
A combination antibiotic pairing a beta-lactamase inhibitor with a monobactam to treat resistant gram-negative bacterial infections.
Key facts at a glance
- RxNorm
- 2705352
- Generic
- Avibactam / Aztreonam
- Class
- multi-ingredient
- Brands
- Emblaveo
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired/ventilator-associated bacterial pneumonia caused by susceptible gram-negative bacteria. Often used when infections involve multi-drug resistant organisms or when standard antibiotics have failed.
Aztreonam is a monobactam antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to bacterial cell death. Avibactam is a beta-lactamase inhibitor that protects aztreonam from degradation by certain beta-lactamase enzymes, thereby extending its spectrum of activity against resistant bacteria.
Administered intravenously. Reserved for use when other treatments are inappropriate due to resistance or safety concerns. Monitor for allergic reactions, particularly in patients with known penicillin or cephalosporin allergies (cross-reactivity risk is low but exists). May cause side effects including gastrointestinal disturbances, liver enzyme elevations, and infusion reactions. Complete the full prescribed course even if symptoms improve.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy