Avapritinib
Ayvakit (avapritinib) is a prescription brand-name medication used to treat certain types of gastrointestinal stromal tumors (GIST). It is specifically indicated for adults with unresectable or metastatic GIST harboring PDGFRA exon 18 mutations, or those who have received prior treatment with other therapies.
Ayvakit is a targeted therapy for certain adults with gastrointestinal stromal tumors (GIST) caused by specific genetic mutations.
Key facts at a glance
- RxNorm
- 2272113
- Generic
- Ayvakit
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with unresectable or metastatic gastrointestinal stromal tumors (GIST) harboring platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutations, including PDGFRA D842V mutations. Also indicated for adult patients with GIST who have received prior treatment with other medications.
Ayvakit is a tyrosine kinase inhibitor that targets and blocks specific mutant proteins (PDGFRA and KIT) that drive the growth of GIST cells.
This is a brand-name medication with no generic available. It may cause serious side effects including cognitive effects, bleeding, and fluid retention. Patients should be monitored for these and other adverse reactions. Genetic testing for PDGFRA mutations is recommended prior to treatment initiation.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy