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Azidocillin Sodium

Published: July 26, 2026Updated: August 24, 2026

Azidocillin Sodium is a penicillin-type antibiotic used to treat bacterial infections. It works by inhibiting bacterial cell wall synthesis, making it effective against susceptible organisms. This medication is typically prescribed for respiratory tract infections, skin infections, and other conditions caused by penicillin-sensitive bacteria.

Quick summary

Azidocillin Sodium is a penicillin antibiotic used to treat various bacterial infections by inhibiting bacterial cell wall growth.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 24, 2026Editorial policy

Key facts at a glance

RxNorm
236787
Generic
Azidocillin Sodium
Class
pin-variant
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Dosage and administration

adult (standard)tablet
Usual dose
500mg twice daily
Maximum
consult physician
Frequency
every 12 hours
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard
pediatric (standard)tablet
Usual dose
250mg twice daily
Maximum
consult physician
Frequency
every 12 hours
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard
geriatric (standard)tablet
Usual dose
400mg daily
Maximum
consult physician
Frequency
once daily
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard

Overdose information

Important overdose information
Toxic dose: Single dose exceeding 10 grams may cause serious toxicity
Chronic overdose: Prolonged high-dose therapy may lead to cumulative toxicity affecting kidneys and nervous system
Immediate actions
Gastric lavage if within 1-2 hours of ingestion, activated charcoal administration, supportive care including airway management and fluid resuscitation
Antidote
No specific antidote available(Treatment is supportive; no antidote exists for penicillin-class antibiotic overdose)
Poison Control: 1-800-222-1222

Special Populations

9 groups
⚠

pregnancy

first trimester
caution
FDA Category
B
Dose Adjustment

use lowest effective dose

Key Recommendations

use only if clearly needed and benefits outweigh potential risks

Monitor

standard prenatal care

Use with caution and monitor for adverse effects.

⚠

pregnancy

second trimester
caution
FDA Category
B
Dose Adjustment

use lowest effective dose

Key Recommendations

use only if clearly needed and benefits outweigh potential risks

Monitor

standard prenatal care

Use with caution and monitor for adverse effects.

⚠

pregnancy

third trimester
caution
FDA Category
B
Dose Adjustment

use lowest effective dose

Key Recommendations

use only if clearly needed benefits outweigh potential risks

Monitor

standard prenatal care

Use with caution and monitor for adverse effects.

✓

lactation

breastfeeding
safe
FDA Category
B
Dose Adjustment

no adjustment needed

Key Recommendations

generally considered compatible with breastfeeding

Monitor

monitor infant for gastrointestinal disturbances

⚠

geriatric

elderly
caution
FDA Category
N
Dose Adjustment

adjust dose based on renal function

Key Recommendations

assess renal function before dosing adjust if creatinine clearance is reduced

Monitor

monitor renal function and for adverse effects

Use with caution and monitor for adverse effects.

⚠

pediatric_age

children
caution
FDA Category
B
Dose Adjustment

dose based on weight

Key Recommendations

use in children only for indicated infections under medical supervision

Monitor

monitor for allergic reactions and gastrointestinal effects

Use with caution and monitor for adverse effects.

⚠

renal_impairment

mild to moderate
caution
FDA Category
N
Dose Adjustment

dose reduction may be required

Key Recommendations

reduce dose in patients with creatinine clearance below 30 mL/min

Monitor

monitor renal function and drug levels if available

Use with caution and monitor for adverse effects.

⚠

renal_impairment

severe
caution
FDA Category
N
Dose Adjustment

significant dose reduction required

Key Recommendations

use with caution in severe renal impairment reduce dose and extend interval

Monitor

close monitoring of renal function and drug levels

Use with caution and monitor for adverse effects.

⚠

hepatic_impairment

moderate
caution
FDA Category
N
Dose Adjustment

no major adjustment typically required

Key Recommendations

use with caution in hepatic impairment

Monitor

monitor liver function tests

Use with caution and monitor for adverse effects.

Statistics and clinical data

drug_classWHO
2023

Drug class

Value:Penicillin-type antibiotic

Antibiotic classification based on chemical structure and mechanism of action

mechanismFDA
2023

Mechanism of action

Value:Inhibits bacterial cell wall synthesis

Pharmacological mechanism of action

usageMedical guidelines
2023

Common therapeutic uses

Value:Treatment of susceptible bacterial infections

Approved indications for Azidocillin Sodium

Respiratory tract infections, skin and soft tissue infections, ear infections, and other conditions caused by susceptible bacteria typically treated with penicillin-type antibiotics.

As a beta-lactam antibiotic, azidocillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to bacterial cell death.

Should not be used in patients with penicillin allergy. May cause gastrointestinal side effects and allergic reactions. Effectiveness may be reduced when taken with tetracyclines or macrolides. Complete the full prescribed course even if symptoms improve.

Contraindications

Conditions and patient states where this medication should be avoided or used with caution.

Do not use (1)

ABSOLUTEhypersensitivity

Known allergy to this medication or its components

Use caution (1)

RELATIVEpregnancy

Consult healthcare provider for benefits vs risks assessment

Official drug label

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy