Azilsartan Kamedoxomil
Azilsartan Kamedoxomil is a prodrug of azilsartan, an angiotensin II receptor blocker (ARB) used to treat hypertension. Once converted to its active form in the body, it helps relax blood vessels by preventing the action of angiotensin II, a hormone that causes vessel constriction.
An antihypertensive medication that lowers blood pressure by blocking angiotensin II receptors.
Key facts at a glance
- RxNorm
- 1294597
- Generic
- Azilsartan Kamedoxomil
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 40-80mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- not established
- Maximum
- consult physician
- Frequency
- N/A
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 40mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteravoid use
discontinue use when pregnancy is detected
regular fetal ultrasound monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second third trimestercontraindicated
do not use during second and third trimesters
close fetal monitoring for growth and amniotic fluid
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid or discontinue breastfeeding
not recommended during breastfeeding due to potential adverse effects in infant
monitor infant for hypotension, hyperkalemia, renal function
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlystart at low dose
initiate therapy at lower dose and titrate cautiously
monitor blood pressure, renal function, potassium levels
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentssafety and efficacy not established
not recommended for use in children under 18 years due to limited data
regular monitoring if used off-label
renal_impairment
moderate to severeuse with caution, may require dose reduction
monitor renal function and potassium during therapy
regular monitoring of serum creatinine and potassium
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderateno initial dose adjustment needed
use with caution in hepatic impairment
monitor blood pressure and liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
Drug class
Drug class information for Azilsartan Kamedoxomil
Common uses
Primary therapeutic indication
FDA approval year
FDA approval date for Edarbi brand
Mechanism of action
Pharmacological mechanism of action
Treatment of essential hypertension in adults. May be used alone or in combination with other antihypertensive agents.
As an angiotensin II receptor blocker (ARB), this medication binds to AT1 receptors, preventing angiotensin II from causing vasoconstriction and aldosterone release, thereby promoting blood vessel relaxation and reduced blood pressure.
Not recommended during pregnancy (especially second and third trimesters) due to potential fetal harm. May cause dizziness or hypotension. Patients with bilateral renal artery stenosis or history of angioedema should use with caution. Drug interactions possible with potassium-sparing diuretics and ACE inhibitors.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy