Azilsartan Medoxomil
Azilsartan Medoxomil is an angiotensin II receptor blocker (ARB) used to treat high blood pressure in adults. It helps relax and widen blood vessels by blocking the action of angiotensin II, a hormone that causes vessels to narrow. This medication is typically prescribed when lifestyle changes alone are insufficient to control blood pressure.
Azilsartan Medoxomil is an ARB medication that lowers blood pressure by blocking angiotensin II, a hormone that constricts blood vessels.
Key facts at a glance
- RxNorm
- 1091642
- Generic
- Azilsartan Medoxomil
- Class
- pin-variant
- Brands
- Edarbi, Edarbyclor
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 40-80mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 20-40mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 40mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second and third trimesterdiscontinue use
do not use during second and third trimester - contraindicated due to risk of fetal renal failure and death
discontinue immediately if pregnancy detected
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingdiscontinue or do not use
not recommended during breastfeeding - drug excreted in breast milk
monitor infant for hypotension
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderlystart at low end of dose range
initiate therapy at lower dose and monitor closely for hypotension and renal function
monitor blood pressure and renal function regularly
Use with caution and monitor for adverse effects.
pediatric_age
children adolescentsnot established
not recommended for patients under 18 years due to insufficient safety and efficacy data
not applicable
renal_impairment
severe renal impairmentuse with caution, no specific dose adjustment
use with caution in patients with severe renal impairment - monitor renal function and avoid in bilateral renal artery stenosis
monitor renal function and serum potassium regularly
Use with caution and monitor for adverse effects.
renal_impairment
moderate renal impairmentno dose adjustment required
no initial dose adjustment needed but monitor renal function
periodic monitoring of renal function
Use with caution and monitor for adverse effects.
hepatic_impairment
hepatic impairmentno dose adjustment required
no dose adjustment needed for mild to moderate hepatic impairment - use with caution
monitor blood pressure and liver function tests
Use with caution and monitor for adverse effects.
Statistics and clinical data
Drug class
Pharmacological classification of Azilsartan Medoxomil
FDA approval year
Regulatory approval information for Azilsartan Medoxomil
Common therapeutic use
Primary therapeutic indication for Azilsartan Medoxomil
Mechanism of action
Pharmacological mechanism of action
Azilsartan Medoxomil is primarily indicated for the treatment of hypertension (high blood pressure) in adults. It may be used alone or in combination with other antihypertensive agents. Controlling high blood pressure helps prevent strokes, heart attacks, and kidney problems.
Azilsartan Medoxomil is a prodrug that is converted to its active form, azilsartan, after oral administration. It works by selectively blocking the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This inhibition prevents angiotensin II's vasoconstrictive and aldosterone-secreting effects, resulting in vasodilation and reduced blood pressure.
Azilsartan Medoxomil should not be used during pregnancy, particularly in the second and third trimesters, as it may cause harm to the developing fetus. Common side effects may include dizziness, diarrhea, and fatigue. Patients should avoid potassium supplements and salt substitutes containing potassium unless directed by their healthcare provider, as ARBs can increase potassium levels. This medication may interact with other drugs, including NSAIDs and lithium. Patients with a history of angioedema, renal impairment, or hepatic impairment should use this medication with caution and under medical supervision.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy