Bacitracin / Hydrocortisone / Neomycin / Polymyxin B
This combination medication combines two antibiotics (bacitracin and neomycin) that work against gram-positive bacteria, an additional antibiotic (polymyxin B) effective against gram-negative bacteria, and a corticosteroid (hydrocortisone) to reduce inflammation. It is used topically to treat and prevent infection while reducing redness, swelling, and itching of the skin.
A topical combination medication containing multiple antibiotics and a corticosteroid for treating infected or inflamed skin conditions.
Key facts at a glance
- RxNorm
- 689623
- Generic
- Bacitracin / Hydrocortisone / Neomycin / Polymyxin B
- Class
- multi-ingredient
- Brands
- Neo-Polycin HC
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used to treat skin infections caused by susceptible bacteria, including minor burns, cuts, scrapes, and skin irritations where infection is present or likely. May also be used for inflammatory skin conditions with risk of bacterial infection.
The antibiotic components (bacitracin, neomycin, and polymyxin B) work by killing or preventing the growth of bacteria on the skin surface. Hydrocortisone provides anti-inflammatory effects by reducing the activity of the immune system in the treated area, helping to decrease swelling, redness, and itching.
For topical use only; avoid contact with eyes, nose, and mouth. Do not use on large areas of damaged skin, for extended periods, or under occlusive dressings unless directed by a healthcare provider. Rare risk of hearing or kidney problems with neomycin, particularly if used extensively. Discontinue use and consult a doctor if irritation, rash, or signs of a new infection develop.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy