Bacitracin / Neomycin / Polymyxin B / Pramoxine
This topical medication combines three antibiotics (bacitracin, neomycin, and polymyxin B) with a local anesthetic (pramoxine) to prevent infection and relieve pain and itching in minor skin wounds. It is commonly used for cuts, scrapes, burns, and other superficial skin injuries. The broad-spectrum antibiotic combination targets a wide range of bacteria while the pramoxine provides temporary numbing relief.
A topical antibiotic-anesthetic combination used to prevent infection and relieve pain in minor skin wounds.
Key facts at a glance
- RxNorm
- 466540
- Generic
- Bacitracin / Neomycin / Polymyxin B / Pramoxine
- Class
- multi-ingredient
- Brands
- Tri Biozene, Cuadriderma, Lanabiotic, Spectrocin Plus, Mycitracin Plus Pain Reliever
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of infection in minor cuts, scrapes, burns, and skin abrasions. Provides symptomatic relief of pain and itching associated with these minor skin injuries.
The three antibiotics work through different mechanisms: bacitracin inhibits bacterial cell wall synthesis, neomycin disrupts bacterial protein synthesis, and polymyxin B damages bacterial cell membranes. Together they provide broad-spectrum coverage against many gram-positive and gram-negative bacteria. Pramoxine is a topical anesthetic that temporarily numbs the skin to relieve pain and itching.
For external use only on intact skin. Avoid applying to large areas, deep wounds, or for prolonged periods. May cause skin irritation or allergic reactions, particularly to neomycin. Not recommended for use in eyes or on mucous membranes. Consult a healthcare provider if symptoms worsen or do not improve after a week of use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy