Bacitracin / Polymyxin B
Bacitracin/Polymyxin B is a topical antibiotic combination used to prevent infection in minor cuts, scrapes, and burns. Bacitracin targets gram-positive bacteria while Polymyxin B targets gram-negative bacteria, providing broad-spectrum protection against common skin pathogens.
Topical antibiotic ointment for preventing infections in minor skin injuries.
Key facts at a glance
- RxNorm
- 645555
- Generic
- Bacitracin / Polymyxin B
- Class
- multi-ingredient
- Brands
- Polycin, Polysporin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of minor skin infections caused by susceptible bacteria, including cuts, scrapes, burns, and abrasions. Commonly used as first-aid antibiotic for minor wounds.
Bacitracin inhibits bacterial cell wall synthesis in gram-positive organisms, while Polymyxin B disrupts the bacterial cell membrane in gram-negative organisms. Together they provide complementary broad-spectrum coverage.
For external use only—avoid contact with eyes, nose, or mouth. Discontinue use and consult a healthcare provider if irritation, rash, or allergic reaction occurs. Not for use on deep wounds, animal bites, or serious burns. Rare cases of systemic absorption or nephrotoxicity have been reported with prolonged use over large areas.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy