Bazedoxifene
Bazedoxifene is a selective estrogen receptor modulator (SERM) that is used in combination with conjugated estrogens in postmenopausal women. It helps relieve menopausal symptoms such as hot flashes and prevents postmenopausal osteoporosis while providing endometrial protection. This combination therapy allows women with a uterus to receive estrogen therapy without increased risk of endometrial hyperplasia.
Bazedoxifene is a SERM combined with conjugated estrogens to treat menopause symptoms and prevent bone loss in postmenopausal women while protecting the uterus.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03XC02
- RxNorm
- 1441386
- Generic
- Bazedoxifene
- Class
- atc-g03
- Brands
- Duavee
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
6 groupspregnancy
all trimestersavoid completely
do not use bazedoxifene during pregnancy contraindicated in pregnant women
not applicable - avoid use
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
breastfeedingavoid
do not use bazedoxifene during breastfeeding secretion in breast milk unknown
not applicable - avoid use
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children adolescentsavoid completely
not indicated for use in pediatric patients safety and efficacy not established
not applicable - avoid use
Use of this medication in this population requires careful consideration of risks and benefits.
geriatric
elderly over 65no dose adjustment required
use with caution monitor for adverse effects no dose adjustment needed for patients over 65
regular assessment of efficacy and adverse effects
Use with caution and monitor for adverse effects.
renal_impairment
severe renal impairmentuse with caution
not recommended in severe renal impairment CrCl less than 30 mL/min use with caution
monitor renal function periodically
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentavoid completely
contraindicated in severe hepatic impairment including biliary cirrhosis
not applicable - avoid use
Use of this medication in this population requires careful consideration of risks and benefits.
Statistics and clinical data
FDA approval year
FDA approval for bazedoxifene/conjugated estrogens combination (Duavee)
Drug class
Pharmacological classification based on mechanism of action
Primary indication
Therapeutic use for moderate to severe vasomotor symptoms associated with menopause
Available formulation
Commercial formulation as combination therapy
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy