Bazedoxifene / Conjugated Estrogens
Bazedoxifene/Estrogens, Conjugated is a tissue-selective estrogen complex combining a selective estrogen receptor modulator (SERM) with conjugated estrogens. This combination is used to treat moderate to severe vasomotor symptoms of menopause and to prevent postmenopausal osteoporosis while providing endometrial protection. The bazedoxifene component helps reduce the risk of estrogen-stimulated endometrial growth, potentially eliminating the need for additional progestin therapy.
A combined hormone therapy for menopausal symptoms and osteoporosis prevention that uses a SERM to protect the uterus.
Key facts at a glance
- RxNorm
- 1441391
- Generic
- Bazedoxifene / Estrogens, Conjugated (Usp)
- Class
- multi-ingredient
- Brands
- Duavee
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe vasomotor symptoms (hot flashes, night sweats) associated with menopause and prevention of postmenopausal osteoporosis.
Conjugated estrogens provide estrogen replacement for symptom relief and bone protection, while bazedoxifene acts as a selective estrogen receptor modulator that provides estrogenic effects in bone and cardiovascular tissues while blocking estrogenic effects in the endometrium.
Contraindicated in pregnancy and in patients with known or suspected breast or estrogen-dependent neoplasia. Associated with increased risks of stroke, DVT, and endometrial cancer. Should not be used with progestins. Use with caution in patients with cardiovascular risk factors or history of venous thromboembolism.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy