Belladonna Alkaloids / Caffeine
Belladonna Alkaloids/Caffeine is a combination medication containing anticholinergic compounds from the belladonna plant along with caffeine. It is primarily used to treat tension headaches, migraine headaches, and sometimes menstrual cramps or other pain conditions involving smooth muscle spasms. The belladonna component helps relax smooth muscles and blocks acetylcholine, while caffeine enhances pain relief and may constrict blood vessels in the head.
A combination of anticholinergic belladonna alkaloids and caffeine used to treat tension and migraine headaches by relaxing smooth muscle and enhancing analgesic effects.
Key facts at a glance
- RxNorm
- 1007139
- Generic
- Belladonna Alkaloids / Caffeine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for tension headaches and migraine headaches; may also be prescribed for menstrual cramps, irritable bowel syndrome symptoms, or other conditions involving smooth muscle spasms and associated pain.
Belladonna alkaloids (atropine, scopolamine, hyoscyamine) act as anticholinergics by blocking acetylcholine receptors, reducing smooth muscle contractions and spasms. Caffeine acts as a mild stimulant and enhances the analgesic effects of the belladonna component while potentially promoting vasoconstriction in cerebral blood vessels.
Common side effects include dry mouth, blurred vision, drowsiness, constipation, and urinary retention due to anticholinergic effects. Caffeine may cause insomnia, anxiety, or increased heart rate. Avoid alcohol and other sedatives while taking this medication. Not recommended for patients with glaucoma, urinary retention, or certain heart conditions. Use with caution in elderly patients due to increased sensitivity to anticholinergic effects.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy