Belladonna Alkaloids / Caffeine / Ergotamine / Pentobarbital
This multi-ingredient medication combines ergotamine (a vasoconstrictor), caffeine (to enhance absorption), belladonna alkaloids (for smooth muscle relaxation), and pentobarbital (a barbiturate sedative). It is primarily used for treating migraine and tension-type headaches, working through multiple mechanisms to relieve pain, reduce associated symptoms like nausea, and provide calming effects during headache episodes.
A combination medication for migraine headaches that combines a vasoconstrictor, stimulant, anticholinergic, and sedative.
Key facts at a glance
- RxNorm
- 1007893
- Generic
- Belladonna Alkaloids / Caffeine / Ergotamine / Pentobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used for the treatment of migraine and tension-type headaches. May be prescribed when single-ingredient therapies are insufficient to control headache symptoms.
Ergotamine constricts dilated blood vessels in the brain associated with migraines; caffeine enhances ergotamine absorption and may have independent analgesic effects; belladonna alkaloids provide smooth muscle relaxation and reduce nausea; pentobarbital offers calming and sedative effects.
Contains pentobarbital, a barbiturate with risk of dependence and CNS depression. Ergotamine component causes systemic vasoconstriction and is contraindicated in cardiovascular disease, hypertension, and pregnancy. Use is typically limited to short-term, intermittent treatment due to risk of medication overuse headache. Requires careful monitoring and should not be stopped abruptly.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy