Belladonna Alkaloids / Ergotamine / Phenobarbital
This combination medication contains belladonna alkaloids, ergotamine, and phenobarbital. It is used to treat migraine and tension-type headaches. The three ingredients work together to relieve pain, reduce anxiety, and constrict blood vessels in the brain.
A combination medication for migraine and tension headaches that combines pain relief, sedation, and vasoconstriction.
Key facts at a glance
- RxNorm
- 1032187
- Generic
- Belladonna Alkaloids / Ergotamine / Phenobarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of migraine and tension-type headaches, particularly when associated with anxiety or tension.
Ergotamine causes vasoconstriction of cranial blood vessels; belladonna alkaloids provide anticholinergic effects to reduce secretions and smooth muscle spasm; phenobarbital acts as a sedative to relieve anxiety and enhance pain relief.
This medication contains a barbiturate with potential for dependence. It should not be used by patients with cardiovascular disease, hypertension, or pregnancy. Due to ergotamine, it may cause vasoconstriction and should be limited in frequency. This is an older medication that has largely been replaced by newer, safer options. Avoid alcohol and use with caution in elderly patients.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy