Belladonna Extract, USP / Butabarbital
Belladonna Extract USP/Butabarbital is a combination medication pairing an anticholinergic antispasmodic with a barbiturate sedative. This combination is primarily prescribed for treating gastrointestinal disorders accompanied by anxiety or nervous tension, such as peptic ulcers, irritable bowel syndrome, and other spastic bowel conditions. The two components work together to reduce smooth muscle spasms while promoting relaxation and reducing anxiety that may exacerbate symptoms.
An anticholinergic-barbiturate combination used for GI spasms when associated with anxiety or tension.
Key facts at a glance
- RxNorm
- 1008547
- Generic
- Belladonna Extract, Usp / Butabarbital
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of gastrointestinal disorders involving spasms and cramping, including peptic ulcers, irritable bowel syndrome, spastic colitis, and related conditions, particularly when accompanied by anxiety or nervous tension that may worsen symptoms.
Belladonna extract contains tropane alkaloids (primarily hyoscyamine and atropine) that block acetylcholine receptors, reducing smooth muscle contractions in the GI tract. Butabarbital is a barbiturate that acts as a CNS depressant on GABA receptors, providing sedative and anxiolytic effects to address the anxiety component.
Due to the barbiturate component, this medication carries risks of dependence, tolerance, and withdrawal with prolonged use. Anticholinergic effects may cause dry mouth, blurred vision, constipation, and urinary retention. Should be used with caution in elderly patients and avoided in patients with glaucoma, urinary retention, or certain cardiac conditions. May impair mental alertness; alcohol should be avoided.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy