Belladonna Extract, USP / Chlorpheniramine / Phenylephrine / Pyrilamine
This combination medication contains four active ingredients that work together to relieve multiple symptoms of allergic rhinitis and upper respiratory conditions. It provides relief from nasal congestion through phenylephrine, while the two antihistamines (chlorpheniramine and pyrilamine) help reduce sneezing, itching, and watery eyes. The belladonna extract adds anticholinergic effects to dry excess secretions.
A multi-symptom allergy and cold medication combining antihistamines, decongestant, and anticholinergic agents to address congestion, sneezing, runny nose, and itchy eyes.
Key facts at a glance
- RxNorm
- 1007079
- Generic
- Belladonna Extract, Usp / Chlorpheniramine / Phenylephrine / Pyrilamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of nasal congestion, sneezing, runny nose, itchy/watery eyes, and other allergy symptoms associated with hay fever or the common cold. May also be used for sinusitis and rhinitis.
Phenylephrine constricts blood vessels in nasal passages to reduce swelling and congestion. Chlorpheniramine and pyrilamine are first-generation antihistamines that block histamine receptors, reducing allergic symptoms. Belladonna extract provides anticholinergic effects that help dry respiratory secretions.
This medication may cause drowsiness and should be used with caution when operating machinery or driving. Anticholinergic effects may cause dry mouth, blurred vision, constipation, and urinary retention. Avoid use in patients with glaucoma, prostate enlargement, or urinary retention. Not recommended for elderly patients due to increased sensitivity to anticholinergic effects. Consult a healthcare provider before use if pregnant, nursing, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy