Bempedoic Acid / Ezetimibe
Bempedoic Acid/Ezetimibe is a combination cholesterol-lowering medication used in adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need additional LDL-C lowering. It combines two complementary mechanisms to reduce cholesterol levels when diet and statins alone are insufficient.
A dual-mechanism cholesterol-lowering combination drug for patients needing additional LDL reduction beyond statins alone.
Key facts at a glance
- RxNorm
- 2283229
- Generic
- Bempedoic Acid / Ezetimibe
- Class
- multi-ingredient
- Brands
- Nexlizet
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hyperlipidemia, specifically heterozygous familial hypercholesterolemia and established atherosclerotic cardiovascular disease, in adults who require additional LDL-C reduction alongside diet and maximally tolerated statin therapy.
Ezetimibe inhibits intestinal cholesterol absorption by blocking the NPC1L1 transporter in the small intestine, while bempedoic acid inhibits ATP citrate lyase in the liver, reducing cholesterol synthesis. Their complementary pathways provide additive LDL-C lowering effects.
May increase uric acid levels and risk of gout; avoid use with fluoroquinolones due to tendon rupture risk. Contraindicated in pregnancy. Liver function monitoring recommended. Common side effects include upper respiratory infections, muscle spasms, and back pain.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy