Diphenhydramine
Benadryl-D Allergy And Sinus is a combination medication containing an antihistamine (diphenhydramine) and a nasal decongestant (pseudoephedrine). It provides multi-symptom relief for seasonal allergies and sinus congestion, addressing symptoms like sneezing, runny nose, itchy eyes, and nasal stuffiness. This medication is designed for adults and children seeking relief from both allergic reactions and sinus pressure.
Benadryl-D Allergy And Sinus combines an antihistamine with a decongestant to relieve allergy symptoms and nasal congestion.
Key facts at a glance
- RxNorm
- 701329
- Generic
- Benadryl-D Allergy And Sinus
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporarily relieves symptoms associated with hay fever, upper respiratory allergies, or the common cold, including nasal congestion, sinus congestion and pressure, runny nose, sneezing, and itchy, watery eyes.
Diphenhydramine blocks the effects of histamine (a natural substance the body produces during allergic reactions) to reduce allergic symptoms. Pseudoephedrine works as a decongestant by narrowing blood vessels in the nasal passages, reducing swelling and congestion.
Contains a sedating antihistamine that may cause drowsiness; avoid alcohol and driving until you know how you respond. Pseudoephedrine is a stimulant that may cause insomnia, increased heart rate, or elevated blood pressure. Do not use if you have certain conditions (glaucoma, heart disease, high blood pressure, thyroid disorders, diabetes, or urinary problems) without consulting a healthcare provider. Consult a doctor before use if pregnant or breastfeeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy