Benazepril / Hydrochlorothiazide
Benazepril/Hydrochlorothiazide is a combination medication used to treat high blood pressure (hypertension). It contains two drugs that work together: an ACE inhibitor (benazepril) that relaxes blood vessels by blocking a hormone that causes them to narrow, and a thiazide diuretic (hydrochlorothiazide) that helps the kidneys remove excess salt and water from the body. This combination is typically prescribed when a single blood pressure medication is not sufficient to control blood pressure.
A two-drug blood pressure medication combining an ACE inhibitor and diuretic for patients who need additional blood pressure control.
Key facts at a glance
- RxNorm
- 214287
- Generic
- Benazepril / Hydrochlorothiazide
- Class
- multi-ingredient
- Brands
- Lotensin HCT
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Benazepril/Hydrochlorothiazide is used to treat hypertension (high blood pressure) in patients who require combination therapy when single-agent treatment is inadequate.
Benazepril is an ACE inhibitor that blocks the angiotensin-converting enzyme, preventing formation of angiotensin II, a substance that causes blood vessels to constrict, thereby promoting vasodilation. Hydrochlorothiazide is a thiazide diuretic that increases urinary excretion of sodium and water, reducing blood volume and cardiac output. Together, they lower blood pressure through complementary mechanisms.
This medication is contraindicated during pregnancy (may cause fetal harm, especially in 2nd and 3rd trimesters). Common side effects include dizziness, lightheadedness, increased urination, and cough. The diuretic component may cause electrolyte imbalances (low potassium), while the ACE inhibitor may increase potassium levels. Patients with a history of angioedema, kidney disease, or allergy to sulfonamides should use with caution or avoid this medication. Regular monitoring of kidney function and electrolytes is recommended.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy