Benazepril / Spironolactone
Benazepril/Spironolactone is a combination medication that contains an ACE inhibitor and a potassium-sparing diuretic. It is primarily used to treat hypertension and heart failure by reducing fluid retention and relaxing blood vessels.
This combination medication treats high blood pressure and heart failure by combining two drugs that work through different mechanisms to reduce fluid and relax blood vessels.
Key facts at a glance
- RxNorm
- 2566848
- Generic
- Benazepril / Spironolactone
- Class
- multi-ingredient
- Brands
- Cardalis
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Benazepril/Spironolactone is used to treat hypertension (high blood pressure) and heart failure, particularly in patients who may benefit from dual blockade of the renin-angiotensin-aldosterone system.
Benazepril is an ACE inhibitor that blocks the conversion of angiotensin I to angiotensin II, reducing blood vessel constriction. Spironolactone is an aldosterone antagonist that blocks the effects of aldosterone, preventing sodium retention and potassium loss.
This combination may increase potassium levels in the blood, so monitoring is important. It is contraindicated in patients with hyperkalemia, renal impairment, or during pregnancy. Common side effects include dizziness, fatigue, and electrolyte abnormalities.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy