Bendroflumethiazide
Bendroflumethiazide is a thiazide diuretic used to treat high blood pressure and fluid retention (edema). It works by helping the kidneys remove excess salt and water from the body, which decreases blood volume and lowers blood pressure. This medication is commonly prescribed as a first-line treatment for hypertension.
Bendroflumethiazide is a thiazide diuretic that lowers blood pressure and reduces fluid retention by increasing urine production.
Key facts at a glance
- ATC
- C03AA01
- RxNorm
- 1369
- Generic
- Bendroflumethiazide
- Class
- atc-c03
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 2.5mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 1.25mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 1.25mg once daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
8 groupspregnancy
first trimesteravoid if possible
avoid use during pregnancy unless benefits outweigh risks
regular fetal monitoring
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
second trimesteravoid if possible
avoid use unless benefits outweigh risks
regular fetal monitoring and maternal electrolytes
Use of this medication in this population requires careful consideration of risks and benefits.
pregnancy
third trimesteravoid if possible
avoid use close to delivery due to risk of neonatal thrombocytopenia
close fetal monitoring and assessment of maternal electrolytes
Use of this medication in this population requires careful consideration of risks and benefits.
lactation
not recommendeddiscontinue or avoid
thiazides are excreted in breast milk; avoid breastfeeding during treatment
monitor infant for electrolyte disturbances
Use of this medication in this population requires careful consideration of risks and benefits.
pediatric_age
children under 12reduce dose based on weight
use with caution; safety and efficacy not well established in children
monitor electrolytes and renal function
Use with caution and monitor for adverse effects.
geriatric
elderly over 65start with lowest effective dose
increased sensitivity to orthostatic hypotension; monitor closely
regular monitoring of blood pressure, electrolytes, and renal function
Use with caution and monitor for adverse effects.
renal_impairment
mild to moderatemay require dose reduction
use with caution; efficacy may be reduced in severe renal impairment
monitor renal function and electrolytes regularly
Use with caution and monitor for adverse effects.
hepatic_impairment
mild to moderateuse with caution
use with caution; may affect electrolyte balance
monitor electrolytes and liver function
Use with caution and monitor for adverse effects.
Statistics and clinical data
Drug class
Pharmacological classification based on mechanism of action
Commonly prescribed since
Historical prescribing information for hypertension treatment
Common uses
Primary therapeutic indications for thiazide diuretics
Mechanism of action
Primary pharmacodynamic properties
Bendroflumethiazide is primarily used to treat essential hypertension (high blood pressure) and edema associated with conditions such as heart failure, liver disease, and kidney disorders. It may also be used as part of combination therapy for managing fluid overload.
As a thiazide diuretic, bendroflumethiazide acts on the distal convoluted tubules in the kidneys, inhibiting the sodium-chloride cotransporter. This increases sodium and water excretion while promoting potassium retention, reducing overall blood volume and cardiac output to lower blood pressure.
Common side effects include electrolyte imbalances (low potassium, sodium, and magnesium), increased urination, dizziness, and elevated blood sugar. Patients should have their electrolytes monitored regularly. It may increase sun sensitivity and interact with other medications including lithium, digoxin, and other antihypertensives. Adequate hydration is important, but avoid excessive fluid intake.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy