Bendroflumethiazide / Clonidine
Bendroflumethiazide/Clonidine is a combination antihypertensive medication pairing a thiazide diuretic with a centrally-acting alpha-2 agonist. This combination is used when single-agent therapy proves insufficient for controlling high blood pressure, with the two components working through complementary mechanisms to achieve better blood pressure control than either agent alone.
A two-drug antihypertensive combining a diuretic with a centrally-acting agent for improved blood pressure management.
Key facts at a glance
- RxNorm
- 812444
- Generic
- Bendroflumethiazide / Clonidine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primary use is for the treatment of essential hypertension when blood pressure is not adequately controlled with monotherapy. May be considered for patients requiring multiple antihypertensive agents to achieve target blood pressure goals.
Bendroflumethiazide is a thiazide diuretic that reduces fluid volume and promotes sodium/water excretion, while clonidine acts on central alpha-2 adrenergic receptors to reduce sympathetic nervous system activity. Together they provide complementary blood pressure reduction through both volume management and decreased vascular resistance.
May cause drowsiness, dry mouth, or dizziness (particularly from clonidine). Avoid abrupt discontinuation of clonidine as it can cause rebound hypertension. Regular monitoring of blood pressure, electrolytes, and kidney function is recommended. May interact with other blood pressure medications, NSAIDs, and certain psychiatric drugs.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy