Bendroflumethiazide / Rauwolfia Preparation
Bendroflumethiazide/Rauwolfia Preparation is a combination antihypertensive medication used primarily to treat high blood pressure. It combines a thiazide diuretic with an alkaloid extract from the Rauwolfia plant to lower blood pressure through complementary mechanisms. This older combination medication may be prescribed when single-agent therapy is insufficient for blood pressure control.
A combination antihypertensive medication pairing a diuretic with a plant-derived agent for enhanced blood pressure reduction.
Key facts at a glance
- RxNorm
- 1008897
- Generic
- Bendroflumethiazide / Rauwolfia Preparation
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is primarily indicated for hypertension (high blood pressure) and may also be used for edema associated with heart failure or other conditions. The combination approach is particularly useful when monotherapy fails to adequately control blood pressure.
Bendroflumethiazide is a thiazide diuretic that promotes sodium and water excretion by acting on the distal convoluted tubules in the kidneys, reducing blood volume. Rauwolfia contains reserpine, which depletes catecholamine stores in nerve endings, decreasing sympathetic nervous system activity and further reducing blood pressure through vasodilation and decreased heart rate.
Common side effects may include drowsiness, fatigue, and depression (particularly from the Rauwolfia component). The medication may cause electrolyte disturbances, especially low potassium levels. It should not be discontinued abruptly, and patients should have regular monitoring of blood pressure and electrolytes. This is an older medication class with fewer modern alternatives available today.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy