Bendroflumethiazide / Spironolactone
Bendroflumethiazide/Spironolactone is a combination diuretic medication used to treat fluid retention (edema) and high blood pressure. It combines a thiazide diuretic with a potassium-sparing diuretic to enhance fluid removal while helping preserve potassium levels in the body. This medication is typically prescribed when single-agent therapy is insufficient for controlling blood pressure or managing fluid accumulation.
A combination diuretic used to treat hypertension and edema by removing excess fluid while preserving potassium levels.
Key facts at a glance
- RxNorm
- 1008922
- Generic
- Bendroflumethiazide / Spironolactone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat hypertension (high blood pressure), edema associated with heart failure, liver cirrhosis, and kidney disorders. It may also be prescribed when additional blood pressure control is needed beyond single-agent therapy.
Bendroflumethiazide is a thiazide diuretic that reduces fluid by increasing sodium and water excretion in the kidneys. Spironolactone is a potassium-sparing diuretic that blocks aldosterone, preventing potassium loss while promoting sodium and water excretion. Together, they provide balanced diuresis with reduced risk of low potassium.
Regular monitoring of electrolytes (especially potassium), kidney function, and blood pressure is essential. This medication may cause dizziness or lightheadedness. Patients should inform their doctor of all medications and supplements being taken, as interactions can occur. Those with kidney disease, liver disease, or a history of electrolyte imbalances should use with caution.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy