Belimumab
Benlysta (belimumab) is a biologic medication specifically designed to treat systemic lupus erythematosus (SLE), a chronic autoimmune disease where the immune system attacks healthy tissues. It is administered as an intravenous or subcutaneous infusion and is typically used in patients with active lupus who are already receiving standard therapy.
Benlysta is a monoclonal antibody used to treat systemic lupus erythematosus by reducing abnormal B-cell activity that contributes to autoimmune inflammation.
Key facts at a glance
- RxNorm
- 1092441
- Generic
- Benlysta
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Benlysta is approved for treating active systemic lupus erythematosus (SLE) in adults and children, as well as active lupus nephritis (kidney inflammation caused by lupus). It is generally prescribed for patients with moderate to severe disease who have not responded adequately to standard treatments.
Benlysta is a monoclonal antibody that targets and blocks a protein called B-lymphocyte stimulator (BLyS). By inhibiting BLyS, the medication reduces the survival and activity of abnormal B cells, which are overactive in lupus and contribute to inflammation and tissue damage.
Benlysta is administered by healthcare professionals and requires monitoring for infections during treatment. It may increase the risk of serious infections, infusion reactions, and has not been studied in patients with severe active lupus involving the central nervous system. Patients should be up to date with vaccinations before starting treatment.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy