Benzalkonium / Polyaminopropyl Biguanide
Benzalkonium/Polyaminopropyl Biguanide is a multi-ingredient antiseptic and preservative combination commonly used in ophthalmic solutions and contact lens care products. It provides antimicrobial protection by combining two agents that work against bacteria, fungi, and certain viruses. This combination is frequently found in eye drops, lens solutions, and wound care formulations.
An antiseptic preservative combination used in eye care and contact lens products to prevent microbial contamination.
Key facts at a glance
- RxNorm
- 2375048
- Generic
- Benzalkonium / Polyaminopropyl Biguanide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used as a preservative in ophthalmic solutions including artificial tears and glaucoma medications. Also found in multi-purpose contact lens solutions for disinfection and cleaning, and in some wound irrigation and antiseptic preparations.
Both agents have antimicrobial properties through different mechanisms. Benzalkonium chloride disrupts microbial cell membranes as a quaternary ammonium compound, while polyaminopropyl biguanide damages bacterial cell walls and interferes with microbial metabolism. Together they provide broad-spectrum protection against bacteria, fungi, and some viruses.
May cause eye irritation or allergic reactions in sensitive individuals. Can be absorbed by soft contact lenses, so patients should wait appropriate time after instilling eye drops before inserting lenses. Not typically used as a standalone medication but rather as a preservative component in other formulations. Should be used under healthcare provider guidance for any therapeutic applications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy