Benzethonium / Diphenhydramine / Hydrocortisone
This is a topical combination medication containing an antiseptic (benzethonium), an antihistamine (diphenhydramine), and a mild corticosteroid (hydrocortisone). It is commonly used to relieve itching, redness, and minor skin irritations caused by allergic reactions, insect bites, poison ivy, or eczema. The three ingredients work together to reduce inflammation, block histamine-related itching, and prevent infection in minor skin abrasions.
A topical anti-itch and anti-inflammatory medication combining an antiseptic, antihistamine, and corticosteroid for minor skin irritations and allergic reactions.
Key facts at a glance
- RxNorm
- 1537193
- Generic
- Benzethonium / Diphenhydramine / Hydrocortisone
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Temporary relief of itching, redness, swelling, and discomfort associated with minor skin irritations, allergic skin reactions, insect bites, poison ivy/oak, poison oak, eczema, and dermatitis. Also used for minor cuts, scrapes, or burns to help prevent infection while reducing inflammation.
Hydrocortisone reduces inflammation and swelling by suppressing the local immune response. Diphenhydramine blocks histamine receptors in the skin to relieve itching. Benzethonium provides antiseptic properties to help prevent bacterial growth in damaged skin.
For external use only—avoid contact with eyes and mucous membranes. Do not apply to large areas of skin, broken skin, or use for prolonged periods without medical advice. Not recommended for children under 2 years unless directed by a physician. Discontinue use if rash worsens or symptoms persist beyond 7 days. May cause local skin reactions in sensitive individuals.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy