Benzethonium / Diphenhydramine / Zinc Acetate
This is a topical combination medication used to relieve itching and minor skin irritations. It combines an antihistamine (diphenhydramine) with an antiseptic (benzethonium) and a skin-protecting agent (zinc acetate). This medication is typically applied to the skin for temporary relief of discomfort from conditions like poison ivy, insect bites, or rashes.
Topical anti-itch medication for temporary relief of minor skin irritations and rashes.
Key facts at a glance
- RxNorm
- 1008383
- Generic
- Benzethonium / Diphenhydramine / Zinc Acetate
- Class
- multi-ingredient
- Brands
- Calagel
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Provides temporary relief of itching and discomfort associated with minor skin irritations, including poison ivy, poison oak, poison sumac, insect bites, and other rashes. May also be used for minor burns and sunburns.
Diphenhydramine blocks histamine receptors in the skin to reduce itching. Benzethonium provides antiseptic protection. Zinc acetate acts as an astringent to help protect and soothe the skin.
For external use only. Avoid applying to large areas of the body, open wounds, or broken skin. Do not use near the eyes or mouth. Consult a healthcare provider if symptoms worsen or persist beyond 7 days. Discontinue use if rash, irritation, or allergic reaction occurs.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy