Benzocaine / Calamine
Benzocaine/Calamine is a topical combination medication used to temporarily relieve itching, pain, and discomfort from minor skin irritations such as sunburn, insect bites, rashes, and poison ivy. Benzocaine acts as a local anesthetic to numb the skin, while calamine provides a protective barrier and has drying properties that help soothe irritated skin.
Topical medication combining an anesthetic (benzocaine) with a skin protectant (calamine) to relieve itching and pain from minor skin irritations.
Key facts at a glance
- RxNorm
- 1009041
- Generic
- Benzocaine / Calamine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Relief of itching, pain, and discomfort from minor skin irritations including sunburn, insect bites and stings, poison ivy/oak/sumac, rashes, and eczema. Also used for pruritus (itching) from various causes.
Benzocaine is a local anesthetic that works by blocking nerve signals in the skin to produce temporary numbness. Calamine is a skin protectant containing zinc oxide that forms a protective barrier on the skin, absorbs excess moisture, and has a cooling effect to soothe irritation.
For external use only. Avoid applying to broken skin, large areas of the body, or near eyes and mouth. Do not use in children under 2 years without medical advice. Discontinue use if irritation or allergic reaction occurs. Not for prolonged use. Consult a healthcare provider if symptoms persist beyond 7 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy