Benzocaine / Trimethobenzamide
Benzocaine/Trimethobenzamide is a combination medication used to treat nausea, vomiting, and associated discomfort. Benzocaine provides local anesthetic relief for stomach and digestive tract irritation, while trimethobenzamide acts as an antiemetic to prevent vomiting. This medication is typically prescribed when patients experience both gastrointestinal symptoms requiring symptom control.
A combination antiemetic and local anesthetic for treating nausea, vomiting, and digestive discomfort.
Key facts at a glance
- RxNorm
- 214301
- Generic
- Benzocaine / Trimethobenzamide
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment and prevention of nausea and vomiting, particularly associated with gastrointestinal irritation, gastritis, or postoperative nausea. May be used when both symptom relief and local anesthetic effect are desired.
Trimethobenzamide works as an antiemetic by blocking dopamine receptors in the chemoreceptor trigger zone and potentially other mechanisms involved in the vomiting reflex. Benzocaine provides local numbing of the gastric mucosa, helping to relieve irritation and discomfort in the digestive tract.
May cause drowsiness or dizziness. Avoid alcohol and other CNS depressants. Use with caution in patients with Parkinson's disease, liver disease, or electrolyte imbalances. Not recommended for use in young children due to risk of methemoglobinemia with benzocaine. Consult healthcare provider before use if pregnant, breastfeeding, or taking other medications.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy