Benzoyl Peroxide / Erythromycin
Benzoyl Peroxide/Erythromycin is a topical combination medication used to treat inflammatory acne. It works through two mechanisms: benzoyl peroxide reduces oil production and unclogs pores, while erythromycin kills acne-causing bacteria. This combination is particularly effective for moderate acne that hasn't responded to single-agent therapy.
A topical acne treatment combining an antibacterial agent with an antibiotic to reduce inflammation and kill acne-causing bacteria.
Key facts at a glance
- RxNorm
- 392556
- Generic
- Benzoyl Peroxide / Erythromycin
- Class
- multi-ingredient
- Brands
- Benzamycin
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treats inflammatory acne vulgaris, including papules, pustules, and nodules. Often prescribed when single-ingredient acne treatments have been ineffective.
Benzoyl peroxide works as a keratolytic agent to reduce comedones (clogged pores) and has mild antibacterial properties. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis, specifically reducing Cutibacterium acnes on the skin.
May cause skin dryness, redness, and peeling—start with less frequent application. Avoid contact with eyes, mouth, and mucous membranes. May bleach hair or fabrics. Antibiotic resistance is a concern with prolonged use, so treatment duration is typically limited. Sun exposure may increase irritation.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy