Benzoyl Peroxide / Tretinoin
Benzoyl Peroxide/Tretinoin is a topical combination medication used to treat acne vulgaris. Benzoyl peroxide works as a keratolytic agent to reduce bacteria and excess oil, while tretinoin promotes cell turnover to prevent pore clogging. This combination is typically prescribed when single-agent acne treatments have been insufficient.
A topical acne treatment combining two active ingredients that work together to reduce bacteria, unclog pores, and promote skin cell turnover.
Key facts at a glance
- RxNorm
- 2565804
- Generic
- Benzoyl Peroxide / Tretinoin
- Class
- multi-ingredient
- Brands
- Twyneo
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Primarily used to treat acne vulgaris (common acne), including inflammatory papules, pustules, and comedones. Often prescribed for moderate acne when over-the-counter treatments have not been effective enough.
Benzoyl peroxide penetrates pores and releases oxygen to reduce anaerobic acne-causing bacteria. Tretinoin, a retinoid derivative of vitamin A, normalizes cell turnover and prevents the formation of new comedones (blackheads and whiteheads). Together they address multiple acne-causing factors.
May cause significant skin irritation, dryness, and peeling especially during the initial weeks of treatment. Sun sensitivity is increased, so sunscreen use is recommended. Usually applied once daily in the evening. May bleach hair or fabrics. Contact with eyes, mouth, and mucous membranes should be avoided.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy