Benzthiazide / Triamterene
Benzthiazide/Triamterene is a combination diuretic medication used to treat high blood pressure and fluid retention (edema). It combines a thiazide diuretic with a potassium-sparing agent to balance fluid removal while helping preserve normal potassium levels. This medication is typically prescribed when single-agent diuretic therapy is insufficient.
A combination diuretic that removes excess fluid while helping maintain potassium balance, used for hypertension and edema management.
Key facts at a glance
- RxNorm
- 392492
- Generic
- Benzthiazide / Triamterene
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of hypertension (high blood pressure) and management of edema associated with heart failure, liver cirrhosis, or kidney dysfunction.
Benzthiazide inhibits sodium reabsorption in the distal tubule, promoting water and salt excretion, while triamterene blocks sodium channels in the collecting duct to retain potassium, creating a balanced diuretic effect.
May cause hyperkalemia (elevated potassium), especially in patients with kidney impairment. Avoid potassium supplements and NSAIDs. Can cause photosensitivity. Monitor kidney function and electrolytes regularly. May interact with ACE inhibitors, ARBs, and lithium.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy