Benzyl Alcohol / Calamine / Diphenhydramine
This combination topical medication is used to relieve itching, irritation, and discomfort from various skin conditions. It combines an antihistamine (diphenhydramine) with a skin protectant (calamine) and a mild antiseptic (benzyl alcohol) to address multiple symptoms simultaneously.
A topical combination medication for relieving itching and skin irritation from minor rashes, insect bites, and allergic reactions.
Key facts at a glance
- RxNorm
- 1298466
- Generic
- Benzyl Alcohol / Calamine / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
This medication is used to treat itching and irritation caused by poison ivy, poison oak, poison sumac, insect bites, minor skin irritations, and allergic skin reactions.
Diphenhydramine blocks histamine to reduce allergic itching, calamine provides a cooling sensation and protects irritated skin, and benzyl alcohol acts as a mild antiseptic while providing local anesthetic relief.
For external use only; avoid contact with eyes, nose, or mouth. Do not use on large areas of damaged or broken skin. Consult a healthcare provider before use in children under 2 years old. Discontinue use and seek medical attention if symptoms worsen or persist beyond 7 days.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy