Bepridil Hydrochloride
Bepridil Hydrochloride is a non-dihydropyridine calcium channel blocker that was primarily used for the treatment of angina pectoris. It works by blocking calcium channels in cardiac and vascular tissue, leading to vasodilation and reduced cardiac workload. Due to significant cardiac safety concerns, including the risk of serious arrhythmias, this medication has been withdrawn from most markets worldwide and is rarely prescribed today.
A calcium channel blocker formerly used for angina that has been largely discontinued due to cardiac safety risks.
Key facts at a glance
- RxNorm
- 235752
- Generic
- Bepridil Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Chronic stable angina pectoris (typically as a second or third-line agent when other antianginal medications are ineffective or contraindicated)
Bepridil blocks L-type calcium channels in cardiac and vascular smooth muscle cells, preventing calcium influx. This results in coronary and peripheral vasodilation, reduced myocardial contractility, and decreased cardiac oxygen demand, thereby alleviating anginal symptoms.
This medication carries a BLACK BOX WARNING for potentially fatal cardiac arrhythmias, including Torsades de Pointes, due to QT prolongation. Requires baseline and periodic ECG monitoring. Has been withdrawn from markets in the United States, Europe, and Japan. Not recommended as first-line therapy; reserved for refractory cases when other treatments fail. Requires careful electrolyte monitoring and avoidance of other QT-prolonging drugs.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy