Berotralstat Hydrochloride
Berotralstat Hydrochloride is an oral medication used for the prevention of hereditary angioedema (HAE) attacks in adult and pediatric patients aged 12 years and older. It works by inhibiting plasma kallikrein, an enzyme involved in the inflammatory process that causes angioedema symptoms.
Oral prophylactic treatment for hereditary angioedema that inhibits plasma kallikrein to reduce attack frequency.
Key facts at a glance
- RxNorm
- 2467541
- Generic
- Berotralstat Hydrochloride
- Class
- pin-variant
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prophylaxis of hereditary angioedema (HAE) in adults and pediatric patients 12 years and older. Not indicated for acute HAE attack treatment.
Berotralstat is a small molecule plasma kallikrein inhibitor that reduces bradykinin production, thereby decreasing vascular permeability and preventing the swelling episodes characteristic of HAE.
Taken orally once daily with food. Common side effects may include abdominal pain, diarrhea, and vomiting. Patients should have rescue medication available for acute attacks. Liver function monitoring may be recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy