Inotuzumab Ozogamicin
Besponsa (inotuzumab ozogamicin) is a targeted therapy medication known as an antibody-drug conjugate used to treat adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). It works by delivering a cytotoxic agent directly to cancer cells that express the CD22 protein, which is commonly found on the surface of B-cell leukemia cells.
Besponsa is a CD22-directed antibody-drug conjugate used to treat relapsed or refractory B-cell acute lymphoblastic leukemia in adults.
Key facts at a glance
- RxNorm
- 1942955
- Generic
- Besponsa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Besponsa is indicated for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL). It is typically used in patients who have undergone prior therapy.
Besponsa is an antibody-drug conjugate that consists of a monoclonal antibody targeting the CD22 protein (found on B-cell surfaces) linked to a cytotoxic agent (ozogamicin). When the antibody binds to CD22 on cancer cells, the drug is internalized and releases its cytotoxic payload, causing DNA damage and triggering cell death.
Besponsa carries a boxed warning for severe hepatotoxicity, including fatal liver failure and veno-occlusive disease/sinusoidal obstruction syndrome. Common side effects include thrombocytopenia, neutropenia, anemia, leukopenia, fatigue, fever, nausea, headache, and liver enzyme elevations. It may cause infusion-related reactions and QT prolongation. The medication is not recommended during pregnancy as it can cause harm to an unborn baby.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed September 3, 2026. · Read our editorial policy