Betamethasone / Hydroquinone / Tretinoin
This combination topical medication contains a corticosteroid (betamethasone), a skin-lightening agent (hydroquinone), and a retinoid (tretinoin). It is primarily prescribed for the treatment of melasma and other skin pigmentation disorders, working to reduce inflammation, lighten dark spots, and promote skin cell turnover.
A triple-agent topical treatment for melasma and hyperpigmentation that combines anti-inflammatory, skin-lightening, and cell-renewing properties.
Key facts at a glance
- RxNorm
- 1651569
- Generic
- Betamethasone / Hydroquinone / Tretinoin
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of moderate to severe melasma (a condition causing brown to gray-brown patches on the face), as well as other hyperpigmentation conditions where darkness is accompanied by inflammation.
Betamethasone reduces skin inflammation and suppresses melanin production; hydroquinone inhibits the enzyme tyrosinase to decrease melanin synthesis; tretinoin accelerates skin cell turnover to help remove pigmented skin cells and enhance penetration of other agents.
For external use only on the skin; typically applied once daily as a thin layer; may cause skin irritation, dryness, or increased sun sensitivity; sunscreen use is strongly recommended; usually prescribed for limited treatment courses (weeks to months) to minimize side effects from the corticosteroid component.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy