Bifonazole / Diphenhydramine
Bifonazole/Diphenhydramine is a topical combination medication pairing an antifungal agent with an antihistamine. This combination is typically used to treat fungal skin infections accompanied by itching, inflammation, or allergic-type reactions at the affected site.
Topical antifungal-antihistamine combination for treating fungal infections with associated itching and inflammation.
Key facts at a glance
- RxNorm
- 1008872
- Generic
- Bifonazole / Diphenhydramine
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Used for fungal skin infections such as tinea (ringworm), athlete's foot, and jock itch when symptoms include significant itching, redness, or allergic-type inflammatory responses at the infection site.
Bifonazole is an imidazole antifungal that inhibits ergosterol synthesis in fungal cell membranes. Diphenhydramine is a first-generation antihistamine that blocks H1 receptors, reducing itching, swelling, and allergic inflammation.
For external use only; avoid application on broken or severely irritated skin. May cause local skin reactions such as burning, redness, or dryness. Consult a healthcare provider if symptoms worsen or do not improve after 2-4 weeks of treatment. Not recommended for use in children under 2 years without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy