Bifonazole / Urea
Bifonazole/Urea is a combination antifungal medication used primarily to treat fungal infections of the nails and skin, particularly those with thickened or hyperkeratotic areas. The urea component helps soften and break down keratin, allowing the bifonazole antifungal to penetrate more effectively into infected tissue. This combination is particularly useful for treating onychomycosis (fungal nail infections) and hyperkeratotic forms of tinea pedis.
A topical antifungal combination that treats fungal infections with thickened skin by combining an antifungal agent with a keratolytic to improve drug penetration.
Key facts at a glance
- RxNorm
- 1008320
- Generic
- Bifonazole / Urea
- Class
- multi-ingredient
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of dermatophyte infections including tinea pedis (athlete's foot), tinea corporis, and tinea manuum with hyperkeratosis. Particularly effective for onychomycosis (fungal nail infections) where thickened nail tissue prevents adequate penetration of standard antifungals.
Bifonazole is an imidazole antifungal that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, leading to fungal cell death. Urea acts as a keratolytic agent that breaks down keratin in thickened skin and nails, allowing bifonazole to reach the infection site more effectively.
For topical use only; avoid contact with eyes and mucous membranes. May cause local skin irritation, redness, or peeling at application site. Those allergic to imidazole antifungals or urea should avoid use. Treatment duration varies based on infection severity; nail infections typically require several months of consistent application. Consult a healthcare provider for proper diagnosis before use.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 28, 2026. · Read our editorial policy