Binimetinib
Binimetinib is an antineoplastic medication classified as a MEK inhibitor, used primarily in combination with other agents for the treatment of certain melanomas with BRAF mutations. It works by targeting the MEK proteins in the ERK signaling pathway to inhibit cancer cell proliferation and survival.
Binimetinib is a targeted cancer therapy that inhibits MEK1/MEK2 enzymes to treat certain BRAF-mutant melanomas.
Key facts at a glance
- ATC
- L01EE03
- RxNorm
- 2049122
- Generic
- Binimetinib
- Class
- atc-l01
- Brands
- Mektovi
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Binimetinib is indicated for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with encorafenib.
Binimetinib is a reversible, selective inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2. By inhibiting these enzymes, it blocks the ERK signaling pathway, which is a critical pathway for cell growth, proliferation, and survival in certain cancer cells.
Common side effects may include fatigue, nausea, diarrhea, and visual disturbances. Binimetinib should only be used in patients whose tumors have confirmed BRAF mutations. Regular monitoring of cardiac function and liver enzymes may be required during treatment. Always use as directed by an oncologist.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy