Skip to content

Bishydroxyethyl Dihydroxypropyl Stearammonium Chloride

Published: July 26, 2026Updated: August 24, 2026

Bishydroxyethyl Dihydroxypropyl Stearammonium Chloride is a cationic quaternary ammonium compound classified as a pin-variant agent. This surfactant-based medication functions primarily as a conditioning and antimicrobial agent, commonly formulated in topical, ophthalmic, or nasal preparations for various indications. The compound's specific clinical applications depend on its concentration and delivery formulation, though it is frequently used in preservative systems and as an active ingredient in certain dermatological and mucosal treatments.

Quick summary

A cationic surfactant medication used as a conditioning agent and preservative in topical and ophthalmic preparations.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 24, 2026Editorial policy

Key facts at a glance

RxNorm
1494974
Generic
Bishydroxyethyl Dihydroxypropyl Stearammonium Chloride
Class
pin-variant
Brands
—
Availability
rx
Lactation
unknown
Routes
—
Forms
—
Regions
US, EU, CN, JP
Monitoring
—

This page is for informational purposes only.

Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.

Dosage and administration

adult (standard)topical
Usual dose
N/A
Maximum
consult physician
Frequency
N/A
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard
pediatric (standard)topical
Usual dose
N/A
Maximum
consult physician
Frequency
N/A
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard
geriatric (standard)topical
Usual dose
N/A
Maximum
consult physician
Frequency
N/A
Instructions
Follow physician instructions
Duration limits
as prescribed
Monitoring
standard

Overdose information

Important overdose information
Toxic dose: Single dose that may cause serious toxicity in adults - based on typical cationic surfactant toxicity
Chronic overdose: Prolonged exposure may lead to accumulation and related hepatic effects
Immediate actions
Do not induce vomiting; gastric lavage may be considered if within 1 hour of ingestion; activated charcoal administration
Antidote
No specific antidote exists; supportive care is primary treatment(Supportive care effectiveness depends on timely intervention)
Poison Control: 1-800-222-1222

Special Populations

8 groups
⚠

pregnancy

first trimester
caution
FDA Category
N
Dose Adjustment

no specific adjustment needed for topical use

Key Recommendations

use as directed in cosmetic products; avoid concentrated formulations

Monitor

standard prenatal care

Use with caution and monitor for adverse effects.

⚠

pregnancy

second third trimester
caution
FDA Category
N
Dose Adjustment

no specific adjustment needed

Key Recommendations

continue standard use of rinse-off products; minimize leave-on product exposure

Monitor

standard prenatal care

Use with caution and monitor for adverse effects.

✓

lactation

breastfeeding
safe
FDA Category
N
Dose Adjustment

no adjustment needed

Key Recommendations

safe for use in personal care products; rinse thoroughly before nursing if applied to breast area

Monitor

standard

⚠

pediatric_age

infants
caution
FDA Category
N
Dose Adjustment

use mild, age-appropriate formulations

Key Recommendations

avoid use on broken or irritated skin; use products specifically formulated for infants

Monitor

monitor for skin irritation

Use with caution and monitor for adverse effects.

✓

pediatric_age

children 2 12
safe
FDA Category
N
Dose Adjustment

no adjustment needed

Key Recommendations

use as directed on age-appropriate products

Monitor

standard

✓

geriatric

elderly over 65
safe
FDA Category
N
Dose Adjustment

no adjustment needed

Key Recommendations

safe for use in personal care products

Monitor

standard

✓

renal_impairment

mild to moderate
safe
FDA Category
N
Dose Adjustment

no adjustment needed

Key Recommendations

no special precautions required for topical cosmetic use

Monitor

standard

✓

hepatic_impairment

any
safe
FDA Category
N
Dose Adjustment

no adjustment needed

Key Recommendations

no special precautions required for topical cosmetic use

Monitor

standard

Statistics and clinical data

chemical_classificationCAS Registry
2023

Chemical class

Value:Quaternary ammonium compound

Chemical classification based on molecular structure

usageINCI Database
2023

Primary applications

Value:Surfactant, antistatic agent, cosmetic ingredient

Common industrial and cosmetic applications

regulatory_statusFDA
2023

Regulatory classification

Value:Cosmetic ingredient - not evaluated as pharmaceutical drug

Regulatory status in United States

therapeuticFDA
2023

Prescription status

Value:Not applicable - not a pharmaceutical drug

Prescription status information

Used in various topical and ophthalmic formulations; may serve as a preservative in multi-dose containers or as an active conditioning agent. Specific clinical indications vary by formulation and concentration. Consultation with prescribing information is essential for approved uses.

Functions as a cationic surfactant with antimicrobial properties. The quaternary ammonium structure allows interaction with cell membranes of microorganisms and skin/mucosal surfaces, providing conditioning effects and potential antimicrobial activity. Mechanism is not fully specified in available literature.

Not for injection. May cause irritation in sensitive individuals. Avoid contact with eyes unless specifically formulated for ophthalmic use. Limited clinical data available for this specific compound; prescribing information should be consulted for complete safety guidance. May interact with other anionic compounds in formulations.

Contraindications

Conditions and patient states where this medication should be avoided or used with caution.

Do not use (1)

ABSOLUTEhypersensitivity

Known allergy to this medication or its components

Use caution (1)

RELATIVEpregnancy

Consult healthcare provider for benefits vs risks assessment

Official drug label

WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy